Type III collagen is found as a major structural component in hollow organs such as large blood vessels, uterus and bowel. It is a crucial collagen for our body and skin.

The difference between type I collagen and type III collagen is type I collagen is the main body of normal adult skin (80%), and type III collagen is the main collagen of fetal & baby skin (60%). Type I collagen is thick, forming large-diameter fibrils with horizontal stripes in the body, which is the material basis of scar tissue fibrosis. In wound healing, type I collagen appears in large quantities, resulting in a scar structure that is completely different from normal skin tissue. The texture is hard but not elastic. In contrast, type III collagen is the main component of the reticular fiber in the skin, and the content is more The thinner the high-fiber bundles, the higher the proportion of type III collagen in wound repair, the smoother skin tissue will be. Collagen is mainly synthesized by fibroblasts, but fibroblasts in the adult's own dermis can only synthesize type I collagen. This is also the reason why the proportion of type III collagen decreases while the proportion of type I collagen continues to increase during human growth. We need to replenish type III continually when we get older.